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Xenograft mice model. NMRI nude mice were injected subcutaneously (SC) with 4.5 × 10 6 Huh7 cells. Treatments CT ( n = 9), XON9 ( n = 8) or Sorafenib ( n = 8) were initiated at the onset of tumor growth (approximately 50–100 mm 3 ) ( A ). Tumor growth ( B ) was assessed by measuring tumor volume twice weekly for a total of 25 days. Data are expressed as mean ± SEM. Two-way ANOVA, *** p < 0.001. Kaplan Meyer curves ( C ).

Journal: International Journal of Molecular Sciences

Article Title: XON9—A Glyco-Humanized Polyclonal Antibody Effective Against Hepatocellular Carcinoma

doi: 10.3390/ijms26189185

Figure Lengend Snippet: Xenograft mice model. NMRI nude mice were injected subcutaneously (SC) with 4.5 × 10 6 Huh7 cells. Treatments CT ( n = 9), XON9 ( n = 8) or Sorafenib ( n = 8) were initiated at the onset of tumor growth (approximately 50–100 mm 3 ) ( A ). Tumor growth ( B ) was assessed by measuring tumor volume twice weekly for a total of 25 days. Data are expressed as mean ± SEM. Two-way ANOVA, *** p < 0.001. Kaplan Meyer curves ( C ).

Article Snippet: A subcutaneous heterotopic tumor model was used with immunodeficient NMRI nude female mice (Janvier-Labs, Le Genest-Saint-Isle, France) according to [ ] with some modifications.

Techniques: Injection